solid basic science,
recognized by ECNP award in 2009.

Our team succeeded in


key receptors of addiction


compounds inhibiting these receptors


a therapeutic composition suitable for human


the concept on proper animal models

Kinnov Therapeutics’ proprietary pharmaceutical composition KT-110 is designed
to become a first-in-class therapy for addiction diseases, with the following assets:

High efficacy on different animal models of addiction
Easy transposition to human (drug repurposing)


Kinnov-therapeutics pipeline for KT110



BV06 (2004)

Concept patent delivered in Fr. In study in EU and USA

BV06BIS (2010)

Protection of combinations and compositions for addiction to alcohol treatment

  • Granted in France
  • Granted in Europa
  • Granted in China
  • Granted in Australia
  • Granted in USA

The most important patent (BV06BIS) has been recognized by the major countries with a significative addiction market

Essential point: We have obtained a protection not only on the indication but also on the composition. Consequently, the association is protected whatever the indication.


Protection of combinations and compositions for addiction to other drugs – tabacco…

  • Granted in France
  • Granted in Russia
  • Granted in Ukraine


Kinnov-Therapeutics board is made of experts in addiction. They work on this subject for
more that 20 years and have written dozens of international publications.

Kinnov-Therapeutics board is made of experts of addiction. They works on this subject since more that 20 years and have written dozens of international publications.

  1. The Combination of Marketed Antagonists of α1b-Adrenergic and 5-HT2A Receptors Inhibits Behavioral Sensitization and Preference to Alcohol in Mice: A Promising Approach for the Treatment of Alcohol Dependence. - Trovero F, David S, Bernard P, Puech A, Bizot JC, Tassin JP. PLoS One. 2016 Mar 11;11(3):e0151242. - Link
  2. D-amphetamine improves attention performance in adolescent Wistar, but not in SHR rats, in a two-choice visual discrimination task. - Bizot JC, Cogrel N, Massé F, Chauvin V, Brault L, David S, Trovero F. - Psychopharmacology (Berl). 2015 Sep;232(17):3269-86. doi: 10.1007/s00213-015-3974-2. Epub 2015 Jun 4. - Link
  3. Pleasure: Neurobiological conception and Freudian conception. - Chenu A, Tassin JP. - Encephale. 2014 Apr;40(2):100-7. doi: 10.1016/j.encep.2013.06.003. Epub 2013 Nov 1. Review. French. - Link
  4. Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons. - Lanteri C, Doucet EL, Hernández Vallejo SJ, Godeheu G, Bobadilla AC, Salomon L, Lanfumey L, Tassin JP. - Mol Psychiatry. 2014 Jul;19(7):823-33. doi: 10.1038/mp.2013.97. Epub 2013 Aug 20. - Link
  5. Traumatic stress in rats induces noradrenergic-dependent long-term behavioral sensitization: role of individual differences and similarities with dependence on drugs of abuse. - Toledano D, Tassin JP, Gisquet-Verrier P. - Psychopharmacology (Berl). 2013 Dec;230(3):465-76. doi: 10.1007/s00213-013-3179-5. Epub 2013 Jun 29. - Link
  6. Sustained impairment of α2A-adrenergic autoreceptor signaling mediates neurochemical and behavioral sensitization to amphetamine. - Doucet EL, Bobadilla AC, Houades V, Lanteri C, Godeheu G, Lanfumey L, Sara SJ, Tassin JP. - Biol Psychiatry. 2013 Jul 15;74(2):90-8. doi: 10.1016/j.biopsych.2012.11.029. Epub 2013 Jan 17. - Link
  7. Chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons. - Barik J, Marti F, Morel C, Fernandez SP, Lanteri C, Godeheu G, Tassin JP, Mombereau C, Faure P, Tronche F. - Science. 2013 Jan 18;339(6117):332-5. doi: 10.1126/science.1226767. - Link
  8. Effects of atomoxetine, desipramine, d-amphetamine and methylphenidate on impulsivity in juvenile rats, measured in a T-maze procedure. - Bizot JC, David S, Trovero F. - Neurosci Lett. 2011 Feb 1;489(1):20-4. doi: 10.1016/j.neulet.2010.11.058. Epub 2010 Dec 1. - Link
  9. α7 and β2 nicotinic receptors control monoamine-mediated locomotor response. - Villégier AS, Salomon L, Granon S, Champtiaux N, Changeux JP, Tassin JP. - Neuroreport. 2010 Dec 8;21(17):1085-9. doi: 10.1097/WNR.0b013e328340536a. - Link
  10. Inhibition of monoamine oxidases desensitizes 5-HT1A autoreceptors and allows nicotine to induce a neurochemical and behavioral sensitization. - Lanteri C, Hernández Vallejo SJ, Salomon L, Doucet EL, Godeheu G, Torrens Y, Houades V, Tassin JP. - J Neurosci. 2009 Jan 28;29(4):987-97. doi: 10.1523/JNEUROSCI.3315-08.2009. - Link
  11. Drugs of abuse specifically sensitize noradrenergic and serotonergic neurons via a non-dopaminergic mechanism. - Lanteri C, Salomon L, Torrens Y, Glowinski J, Tassin JP. - Neuropsychopharmacology. 2008 Jun;33(7):1724-34. Epub 2007 Sep 5. - Link
  12. Uncoupling between noradrenergic and serotonergic neurons as a molecular basis of stable changes in behavior induced by repeated drugs of abuse. - Tassin JP. - Biochem Pharmacol. 2008 Jan 1;75(1):85-97. Epub 2007 Jun 30. Review. - Link
  13. Paradoxical constitutive behavioral sensitization to amphetamine in mice lacking 5-HT2A receptors. - Salomon L, Lanteri C, Godeheu G, Blanc G, Gingrich J, Tassin JP. - Psychopharmacology (Berl). 2007 Sep;194(1):11-20. Epub 2007 May 19. - Link
  14. Elevated dopamine D2High receptors in alpha-1b-adrenoceptor knockout supersensitive mice. - Tassin JP, Torrens Y, Salomon L, Lanteri C, Seeman P. - Synapse. 2007 Jul;61(7):569-72. - Link
  15. Methylphenidate reduces impulsive behaviour in juvenile Wistar rats, but not in adult Wistar, SHR and WKY rats. - Bizot JC, Chenault N, Houzé B, Herpin A, David S, Pothion S, Trovero F. - Psychopharmacology (Berl). 2007 Aug;193(2):215-23. Epub 2007 Apr 4. - Link
  16. [Uncoupling between noradrenergic and serotonergic neurons: As a mechanism for drug addiction]. - Tassin JP, Lanteri C, Salomon L. - Med Sci (Paris). 2006 Oct;22(10):798-800. French. No abstract available. - Link
  17. Irreversible blockade of monoamine oxidases reveals the critical role of 5-HT transmission in locomotor response induced by nicotine in mice. - Villégier AS, Salomon L, Blanc G, Godeheu G, Glowinski J, Tassin JP. - Eur J Neurosci. 2006 Sep;24(5):1359-65. Epub 2006 Sep 8. - Link
  18. [Neurobiology in the neuropharmacology of antipsychotic drugs]. - Tassin JP. - Encephale. 2006 Jan;32 Pt 2:S6-7. French. No abstract available. - Link
  19. Behavioral sensitization to amphetamine results from an uncoupling between noradrenergic and serotonergic neurons. - Salomon L, Lanteri C, Glowinski J, Tassin JP. - Proc Natl Acad Sci U S A. 2006 May 9;103(19):7476-81. Epub 2006 Apr 28. - Link
  20. Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine. - Villégier AS, Salomon L, Granon S, Changeux JP, Belluzzi JD, Leslie FM, Tassin JP. - Neuropsychopharmacology. 2006 Aug;31(8):1704-13. Epub 2005 Dec 14. - Link
  21. cAMP and extracellular signal-regulated kinase signaling in response to d-amphetamine and methylphenidate in the prefrontal cortex in vivo: role of beta 1-adrenoceptors. - Pascoli V, Valjent E, Corbillé AG, Corvol JC, Tassin JP, Girault JA, Hervé D. - Mol Pharmacol. 2005 Aug;68(2):421-9. Epub 2005 May 12. - Link
  22. 5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants. - Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP. - Eur J Neurosci. 2004 Dec;20(11):3073-84. - Link
  23. Role of serotonin 2A receptors in the D-amphetamine-induced release of dopamine: comparison with previous data on alpha1b-adrenergic receptors. - Auclair A, Blanc G, Glowinski J, Tassin JP. - J Neurochem. 2004 Oct;91(2):318-26. - Link
  24. Transient behavioral sensitization to nicotine becomes long-lasting with monoamine oxidases inhibitors. - Villégier AS, Blanc G, Glowinski J, Tassin JP. - Pharmacol Biochem Behav. 2003 Sep;76(2):267-74. - Link
  25. Stimulation of postsynaptic alpha1b- and alpha2-adrenergic receptors amplifies dopamine-mediated locomotor activity in both rats and mice. - Villégier AS, Drouin C, Bizot JC, Marien M, Glowinski J, Colpaërt F, Tassin JP. - Synapse. 2003 Dec 15;50(4):277-84. - Link
  26. D-amphetamine fails to increase extracellular dopamine levels in mice lacking alpha 1b-adrenergic receptors: relationship between functional and nonfunctional dopamine release. - Auclair A, Cotecchia S, Glowinski J, Tassin JP. - J Neurosci. 2002 Nov 1;22(21):9150-4. - Link
  27. Amisulpride does not prevent relapse in primary alcohol dependence: results of a pilot randomized, placebo-controlled trial. - Marra D, Warot D, Berlin I, Hispard E, Notides C, Tilikete S, Payan C, Lépine JP, Dally S, Aubin HJ. - Alcohol Clin Exp Res. 2002 Oct;26(10):1545-52. - Link
  28. [Role of dopamine in drug dependence processes]. - Tassin JP. - Bull Acad Natl Med. 2002;186(2):295-304; discussion 304-5. Review. French. - Link
  29. Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates. - Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP. - J Neurosci. 2002 Apr 1;22(7):2873-84. - Link
  30. Critical role of alpha1-adrenergic receptors in acute and sensitized locomotor effects of D-amphetamine, cocaine, and GBR 12783: influence of preexposure conditions and pharmacological characteristics. - Drouin C, Blanc G, Villégier AS, Glowinski J, Tassin JP. - Synapse. 2002 Jan;43(1):51-61. - Link
  31. Cortical alpha 1-adrenergic regulation of acute and sensitized morphine locomotor effects. - Drouin C, Blanc G, Trovero F, Glowinski J, Tassin JP. - Neuroreport. 2001 Nov 16;12(16):3483-6. - Link
  32. Stimulation of metabotropic but not ionotropic glutamatergic receptors in the nucleus accumbens is required for the D-amphetamine-induced release of functional dopamine. - Darracq L, Drouin C, Blanc G, Glowinski J, Tassin JP. - Neuroscience. 2001;103(2):395-403. - Link
  33. Sequential improvement of anxiety, depression and anhedonia with sertraline treatment in patients with major depression. - Boyer P, Tassin JP, Falissart B, Troy S. - J Clin Pharm Ther. 2000 Oct;25(5):363-71. - Link
  34. Integrity of the mesocortical dopaminergic system is necessary for complete expression of in vivo hippocampal-prefrontal cortex long-term potentiation. - Gurden H, Tassin JP, Jay TM. - Neuroscience. 1999;94(4):1019-27. - Link
  35. Ginkgo biloba extract EGb761 reduces the development of amphetamine-induced behavioral sensitization: effects on hippocampal type II corticosteroid receptors. - Trovero F, Brochet D, Tassin JP, Drieu K. - Brain Res. 1999 Feb 6;818(1):135-9. - Link
  36. Alpha1-adrenergic, D1, and D2 receptors interactions in the prefrontal cortex: implications for the modality of action of different types of neuroleptics. - Gioanni Y, Thierry AM, Glowinski J, Tassin JP. - Synapse. 1998 Dec;30(4):362-70. - Link
  37. A functional model of some Parkinson's disease symptoms using a Guided Propagation Network. - Toffano-Nioche C, Beroule D, Tassin JP. - Artif Intell Med. 1998 Nov;14(3):237-58. - Link
  38. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. - François G, Diakanamwa C, Timperman G, Bringmann G, Steenackers T, Atassi G, Van Looveren M, Holenz J, Tassin JP, Assi LA, Vanhaelen-Fastre R, Vanhaelen M. - Int J Parasitol. 1998 Apr;28(4):635-40. - Link
  39. Importance of the noradrenaline-dopamine coupling in the locomotor activating effects of D-amphetamine. - Darracq L, Blanc G, Glowinski J, Tassin JP. - J Neurosci. 1998 Apr 1;18(7):2729-39. - Link
  40. Norepinephrine-dopamine interactions in the prefrontal cortex and the ventral tegmental area: relevance to mental diseases. - Tassin JP. - Adv Pharmacol. 1998;42:712-6. No abstract available. - Link
  41. Sensitivity and specificity to amphetamine of a French version of the 49-item form of the addiction research center inventory. - Warot D, Danjou P, Payan C, Puech AJ. - Drug Alcohol Depend. 1997 May 2;45(3):177-83. - Link
  42. Simultaneous determination of cytotoxic (adriamycin, vincristine) and modulator of resistance (verapamil, S 9788) drugs in human cells by high-performance liquid chromatography and ultraviolet detection. - Tassin JP, Dubois J, Atassi G, Hanocq M. - J Chromatogr B Biomed Sci Appl. 1997 Apr 11;691(2):449-56. - Link
  43. [Schizophrenia and neural transmission: an excess of analogical treatment?]. - Tassin JP. - Encephale. 1996 Oct;22 Spec No 3:91-8. Review. French. No abstract available. - Link
  44. [Deficit schizophrenia: from pharmacology to clinical practice]. - Tassin JP. - Encephale. 1996 Jun;22 Spec No 2:9-12. Review. French. - Link
  45. A reversible monoamine oxidase A inhibitor (moclobemide) facilitates smoking cessation and abstinence in heavy, dependent smokers. - Berlin I, Saïd S, Spreux-Varoquaux O, Launay JM, Olivares R, Millet V, Lecrubier Y, Puech AJ. - Clin Pharmacol Ther. 1995 Oct;58(4):444-52. - Link
  46. HPLC determination of a new multidrug resistance modulator (S9788) extracted from cancer cells in vitro. - Tassin JP, Dubois J, Hanocq M, Atassi G. - Talanta. 1995 May;42(5):747-53. - Link
  47. [Interrelations between neuromediators implicated in depression and antidepressive drugs]. - Tassin JP. - Encephale. 1994 Dec;20 Spec No 4:623-8. Review. French. - Link
  48. Accelerated resensitization of the D1 dopamine receptor-mediated response in cultured cortical and striatal neurons from the rat: respective role of alpha 1-adrenergic and N-methyl-D-aspartate receptors. - Trovero F, Marin P, Tassin JP, Premont J, Glowinski J. - J Neurosci. 1994 Oct;14(10):6280-8. - Link
  49. Le clonage des gènes codant pour les récepteurs opiacés permet-il une meilleure compréhension de la toxicomanie? - Trovero F. - Neuro-psy, 1994, 9, 227-233.
  50. Blockade of prefronto-cortical alpha 1-adrenergic receptors prevents locomotor hyperactivity induced by subcortical D-amphetamine injection. - Blanc G, Trovero F, Vezina P, Hervé D, Godeheu AM, Glowinski J, Tassin JP. - Eur J Neurosci. 1994 Mar 1;6(3):293-8. - Link
  51. Injections of 6-hydroxydopamine into the ventral tegmental area destroy mesolimbic dopamine neurons but spare the locomotor activating effects of nicotine in the rat. - Vezina P, Hervé D, Glowinski J, Tassin JP. - Neurosci Lett. 1994 Feb 28;168(1-2):111-4. - Link
  52. Blockade of D-1 dopamine receptors in the medial prefrontal cortex produces delayed effects on pre- and postsynaptic indices of dopamine function in the nucleus accumbens. - Vezina P, Blanc G, Glowinski J, Tassin JP. - Synapse. 1994 Feb;16(2):104-12. - Link
  53. G(olf) and Gs in rat basal ganglia: possible involvement of G(olf) in the coupling of dopamine D1 receptor with adenylyl cyclase. - Hervé D, Lévi-Strauss M, Marey-Semper I, Verney C, Tassin JP, Glowinski J, Girault JA. - J Neurosci. 1993 May;13(5):2237-48. - Link
  54. Potentiation by low doses of selected neuroleptics of food-induced conditioned place preference in rats. - Guyon A, Assouly-Besse F, Biala G, Puech AJ, Thiébot MH. - Psychopharmacology (Berl). 1993;110(4):460-6. - Link
  55. Drug interaction involving P-glycoprotein in relation to multidrug resistance. - Atassi G, Tassin JP. - Int J Clin Pharmacol Ther Toxicol. 1992 Nov;30(11):526-7. Review. No abstract available. - Link
  56. Inhibitory effects of ventral tegmental area stimulation on the activity of prefrontal cortical neurons: evidence for the involvement of both dopaminergic and GABAergic components. - Pirot S, Godbout R, Mantz J, Tassin JP, Glowinski J, Thierry AM. - Neuroscience. 1992 Aug;49(4):857-65. - Link
  57. In vivo partial inactivation of dopamine D1 receptors induces hypersensitivity of cortical dopamine-sensitive adenylate cyclase: permissive role of alpha 1-adrenergic receptors. - Trovero F, Hervé D, Blanc G, Glowinski J, Tassin JP. - J Neurochem. 1992 Jul;59(1):331-7. - Link
  58. Cortico-subcortical interactions in behavioral sensitization: differential effects of daily nicotine and morphine. - Tassin JP, Vezina P, Trovero F, Blanc G, Hervé D, Glowinski J. - Ann N Y Acad Sci. 1992 Jun 28;654:101-16. Review. No abstract available. - Link
  59. Nicotine and morphine differentially activate brain dopamine in prefrontocortical and subcortical terminal fields: effects of acute and repeated injections. - Vezina P, Blanc G, Glowinski J, Tassin JP. - J Pharmacol Exp Ther. 1992 May;261(2):484-90. - Link
  60. Biochemical and behavioural consequences of interactions between dopaminergic and noradrenergic systems in rat prefrontal cortex. - Tassin JP, Trovero F, Hervé D, Blanc G, Glowinski J. - Neurochem Int. 1992 Mar;20 Suppl:225S-230S. Review. No abstract available. - Link
  61. Contribution of an alpha 1-adrenergic receptor subtype to the expression of the "ventral tegmental area syndrome". - Trovero F, Blanc G, Hervé D, Vézina P, Glowinski J, Tassin JP. - Neuroscience. 1992;47(1):69-76. - Link
  62. Mesocortical dopamine-neurotensin neurons. Possible opposite role of noradrenergic pathways on heteroregulations of dopamine (D1) and neurotensin postsynaptic receptors in the rat prefrontal cortex. - Tassin JP, Trovero F, Hervé D, Blanc G, Glowinski J. - Ann N Y Acad Sci. 1992;668:205-16. Review. No abstract available. - Link
  63. NE/DA interactions in prefrontal cortex and their possible roles as neuromodulators in schizophrenia. - Tassin JP. - J Neural Transm Suppl. 1992;36:135-62. Review. - Link
  64. Autoradiographic identification of D1 dopamine receptors labelled with [3H]dopamine: distribution, regulation and relationship to coupling. - Hervé D, Trovero F, Blanc G, Glowinski J, Tassin JP. - Neuroscience. 1992;46(3):687-700. - Link
  65. Dopaminergic hetero-regulation of striatal mu-opiate receptors: further evidence for their postsynaptic location. In "Presynaptic Receptors and Neuronal Transmission". - Trovero F., Hervé D., Desban M., Glowinski J. and Tassin J.P - Pergamon Press, Oxford. 1991.
  66. Evidence for phosphatidylinositol anchorage of opioid binding proteins in rat brain. - Trovero F, Glowinski J, Lévy M. - Brain Res. 1990 Dec 24;537(1-2):381-5. - Link
  67. Striatal opiate mu-receptors are not located on dopamine nerve endings in the rat. - Trovero F, Herve D, Desban M, Glowinski J, Tassin JP. - Neuroscience. 1990;39(2):313-21. - Link