Preclinical data

Selected composition :

  • Drug1 : Antagonist of 5HT2 and 5HT1C receptors used in the treatment of allergy
  • Drug2 : Antagonist of alpha1-adrenergic receptors used in the treatment of arterial high blood pressure

Addiction to alcohol :

Effects of the combination on the alcohol intake and on preference to alcohol.

The preference to alcohol (vs. water) is studied on five groups of animals treated according to the legend

Drug1 + Drug2 in combination (KT-110 of Kinnov Therapeutics) reduces preference to alcohol and induces a strong alcohol aversion.

Addiction to nicotine :

Effects of KT-110 on behavioral sensitization to nicotine.

Locomotor Activity induced by Nicotine in mice
  • Nicotine induces an hyperactivity that becomes more marked after the 2nd and 3rd injections (Behavioral Sensitization).
  • KT-110 antagonizes behavioral sensitization induced by nicotine