Selected composition :
- Drug1 : Antagonist of 5HT2 and 5HT1C receptors used in the treatment of allergy
- Drug2 : Antagonist of alpha1-adrenergic receptors used in the treatment of arterial high blood pressure
Addiction to alcohol :
Effects of the combination on the alcohol intake and on preference to alcohol.
Drug1 + Drug2 in combination (KT-110 of Kinnov Therapeutics) reduces preference to alcohol and induces a strong alcohol aversion.
Addiction to nicotine :
Effects of KT-110 on behavioral sensitization to nicotine.
- Nicotine induces an hyperactivity that becomes more marked after the 2nd and 3rd injections (Behavioral Sensitization).
- KT-110 antagonizes behavioral sensitization induced by nicotine